Objective
Stroke is a major cause of long-term disability in humans, but effective treatments are lacking. The StemStroke consortium comprises 5 highly qualified academic research teams and one SME which, together with excellent clinicians in the stroke field, will perform innovative research leading to the first preclinical protocol for application of stem cell therapy in stroke patients. Human neural stem cell (NSC) lines will be isolated from the foetal and adult brain, and from embryonic stem cells. Cellular and molecular mechanisms regulating the proliferation, migration, survival, and differentiation of the NSC lines after transplantation into the stroke-damaged rodent brain will be determined.
The StemStroke will explore the morphological and functional integration of grafted and endogenously generated NSCs and their progeny in the stroke-damaged brain, and develop new in vivo imaging and behavioural tests, relevant for the human situation, for assessment of stem cell function and recovery of sensory, motor and cognitive deficits.
Finally, StemStroke will optimize transplantation- and endogenous neurogenesis-based strategies and create an important preclinical protocol which can be rapidly translated into human trials. The teams contain top-level expertise in animal models of stroke and MRI-based in vivo imaging, stem cell, molecular, and cellular biology, molecular genetics, animal behaviour and psychology, translational research, and clinical cell therapy.
Through the participating SME, commercial exploitation of the knowledge emerging from the project is ensured. The complementarity of expertise within the consortium, together with the intellectual and technological resources available from each partner, will ensure efficient and high-quality performance and feasibility of achieving its ambitious S&T goals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences molecular biology molecular genetics
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine neurology stroke
- medical and health sciences clinical medicine transplantation
- natural sciences biological sciences biological behavioural sciences ethology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LUND
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.