Objective
In the 1970's WHO proclaimed that eradication of smallpox should be attempted. This goal has been achieved 1979. There is now consensus that list of newly emerging or re-emerging pathogens is continuously growing. During the last decades pathogens such as Marburg, Ebola, Hepatitis-C and Hantavirus, HIV and more recently, SARS coronavirus have emerged. Today the risk of a new influenza pandemic again highlights the global threat of infectious diseases. In addition, the possibility of bioterrorist attacks using highly pathogenic viruses and bacteria can not be ignored. Furthermore, the requirements for sensitivity and specifity of diagnostics have increased. A major obstacle for the detection of pathogens in clinical or environmental samples are false negative results, e.g. for HCV "occult infections". This is mainly due to the lack of a rapid and reliable pathogen concentration methodology, and the inability of most of the currently used technologies to eliminate or neutralize interfering "natural inhibitors" present in samples. The aim of this research program is to exploit the "non-self" recognition and binding properties of human apolipoprotein H (ApoH). ApoH binds and captures pathogens enabling their concentration from different biological samples. Magnetic beads coated with ApoH recombinant protein can be efficiently used as a pretreatment step to greatly improve the detection threshold and thereby increasing the sensitivity for diagnosis of emerging pathogens, regardless of the molecular techniques used for their diagnosis. The project will focus on viruses and bacteria from clinical and environmental samples including those that could be used in bioterrorism. In addition to the incorporation of ApoH into regular molecular techniques for pathogen detection, mini-array chips will be developed for multiple and ultra-sensitive pathogen diagnosis.'
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BERLIN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.