Objective
A minority (<5%) of all HIV-1 infected individuals have been defined as long-term nonprogressors (LTNP) in that they maintain exceptionally prolonged survival in the absence of clinical symptoms and without receiving antiretroviral therapy. Several cohorts of LTNP have been identified in Europe and national networks have been formed in France and Italy to better study their particular features. GISHEAL is the first collaborative European consortium focusing on the LTNP condition with particular regard to the host genetic background and gene expression profiling and to the adaptive and innate immunological responses to the infection. A common database will be formed by merging two existing national (French, Italian) databases supplemented with additional data collected from LTNP cohorts currently followed-up in the UK and Uganda. A genome-wide approach based on screening of >100,000 single-nucleotide polymorphisms (SNPs) followed by proper validation steps will lead to the potential discovery of novel genetic polymorphisms linked to LTNP in addition to those already described. Their consequence in terms of gene expression will be studied in different populations of leukocytes (CD4, CD8, monocytes, NK and T cells) by microfluidic cards based on multi-parametric real-time PCR (TaqMan) in selected LTNP and control chronic progressors (CP). The adaptive T lymphocyte (CD4, CD8) immune responses as well as the NK cell and T cell responses to HIV will be studied in LTNP and CP. The functional consequences of the potentially novel genetic and post-genomic correlates of therapy-independent long-term non-progression in HIV infection will be also investigated in these immune cells. A multivariate analysis will allow definition of the best correlates of non-progression that could be of relevance to the general population of HIV-infected individuals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences databases
- medical and health sciences basic medicine immunology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences genetics nucleotides
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-6
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MILAN
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.