Contribution of molecular epidemiology and host-pathogen genomics to understand Chlamydial trachomatis disease

Objective

Chlamydia trachomatis (CT) infections are responsible for both the world leading cause of blindness (trachoma) and the most prevalent sexually transmitted disease which is strongly associated with pelvic inflammatory disease, ectopic pregnancy, and tubal infertility. Preliminary twin study-based findings of members of this consortium estimate that there is a 40% genetic predisposition to CT infections. In order to fully exploit human genomics in the battle against CT infections, it is necessary to reliably determine aforementioned genetic predisposition at the gene level to CT infection and to define a genetic fingerprint that can be used as a marker for this predisposition. The EpiGenChlamydia CA aims to structure trans-national research to such degree that comparative genomics and genetic epidemiology on large numbers of unrelated individuals can be performed.

Fields of science

Programme(s)

FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006.

Topic(s)

Call for proposal

FP6-2005-LIFESCIHEALTH-6
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Funding Scheme

CA - Coordination action

Coordinator

Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patientenzorg, Waarvan Uitgaat vu Medisch Centrum (Vu University Medical Centre)

Address

De Boelelaan 1105
Amsterdam
Netherlands