Objective
The overall aim of the proposed project is to improve the outcome of cancer chemotherapy by developing novel tools to predict tumour response to treatment as well as individual toxicity to chemotherapy. The projectwill seek to identify and validate mechanisms of intrinsic and acquired chemotherapy resistance, as well as predictors of efficacy and of individual toxicity. This is achieved by integrating the work of groups conducting large clinical trials with preclinical research groups, as well as with state of the art-platforms for genomic and proteomic analyses and bioinformatics.
The participants have chosen to focus on melanoma and lung cancer as model tumours of separate histogenetic types exhibiting intrinsic resistance and/or a high degree of acquired resistance to chemotherapy. Candidate mechanisms of drug resistance and therapeutic efficacy will be identified using genomic and proteomic analyses of sequential tumour samples and paired sera obtained before and after chemotherapy as well as experimental systems, including in vitro studies of tumour cell lines, transplanted human tumours and novel animal tumour models,. These putative mechanisms will then be validated in further analyses of larger sets of tumour biopsies from patients. Functional studies of novel mechanisms and pathways will be also performed using in-vitro systems and animal models.
The result of these activities will thus be a set of clinically and functionally validated mechanisms of chemotherapy resistance and therapeutic efficacy. Likewise, large scale genomic analyses of patients receiving chemotherapy as part of clinical trials will be performed in order to validate novel markers of individual toxicity following chemotherapy.The novel knowledge obtained through the project will lead to new tools for prediction of treatment outcome as well as toxicity of chemotherapy. This knowledge may also be used to identify and prepare for preclinical development of potential novel modulator.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences clinical medicine oncology lung cancer
- medical and health sciences clinical medicine oncology skin cancer melanoma
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.