Objective
Compulsive disorders, including drug abuse and compulsive overeating, represent prevalent neuropsychiatric diseases that have a large health and socio-economic impact on the European population. These disorders are produced by an alteration of the capability to control seeking for reward and are apparently linked by common neurobiological substrates. However, there is an important gap in the availability of reliable behavioural models in animals that permit the investigation of compulsion towards reward in the perspective of human pathologies. The present proposal will use new sophisticated behavioural and neuroimaging techniques for the characterisation of four new and complementary animal models of compulsive disorders, allowing to precisely analyse the main components of those behavioural alterations. The studies will be performed in mice and rats, including the transfer of rat models to mice when necessary. Novel behavioural paradigms will be proposed, tested and validated within the project taking advantage from cutting-edge imaging technologies. Molecular studies will characterise changes induced in several key elements of the reward circuits during these behavioural disorders. The behavioural and molecular characterisation of the models, along with parallel neuroimaging (PET), will provide a complete anatomical and functional illustration of the reward pathways imbalance in the above-mentioned pathological situations. After the full characterisation of the models, they will be used on mice genetically modified for glucocorticoid receptors to ascertain correlations between behavioural and genetic components of compulsion in drug addiction and eating disorders. Hence, reliable and predictive animal models will be fully characterised and employed to better understand the mechanisms involved in those alterations and to design new therapeutic strategies in neuropsychiatric disorders related to compulsive behaviour.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences substance abuse
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-7
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.