Objective
Insulin resistance, the key feature of the metabolic syndrome, not only causes type 2 diabetes but also gives rise to its deadliest complications - the cardiovascular disease. A key factor in the development of insulin resistance is the accumulation of triglycerides in liver and muscle, a process that seems to be highly regulated. NACARDIO is a multidisciplinary project aiming to develop and commercialise a nano-biosensor technology, capable of analysing extremely small amounts of protein in small sample volumes. The technology can be used to quantify proteins involved in lipid storage to investigate if any of these proteins are potential biomarkers for the development of insulin resistance and cardiovascular disease. The sensor technology is based on single electron tunnelling (SET), a phenomenon well explored for low temperature applications. State of the art nanofabrication utilising metallic nanoparticles now make this technology platform available for room temperature operation. SET-technology provides unique possibilities for biosensing. Direct electrical detection can be made with sensitivity greater than for any other existing or proposed technique. To achieve the goals of NACARDIO, extensive multidisciplinary work addressing questions at the interface between nanotechnology, physics, electrical engineering, surface chemistry, biotechnology and medical sciences will be performed. Frontline experimental approaches encompassing peptide-stabilised gold nanoparticles, electron-beam lithography, nano-imprint, molecular self-assembly, engineered antibody-fragments, protein expression and fluidic simulations will be employed to fabricate the sensor and ensure biological functionality and usability. The efforts will result in a technology that not only revolutionises cardiovascular research and diagnostics, but also promotes other innovative approaches including analyses of extremely small sample (e.g. single-cell) and real-time monitoring of cell-signalling.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- engineering and technology nanotechnology nano-materials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-6
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GÖTEBORG
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.