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Content archived on 2024-06-16

HIV protease inhibitor resistance by enzyme-substrate coevolution

Objective

Despite the success of antiretroviral drugs, therapy of HIV/AIDS still suffers from severe drawbacks because of undesired consequences of therapy. The major undesired consequence is resistance which renders individual drugs and complete drug classes ineffective. 70-80% of HIV-infected patients undergoing resistance testing carry drug resistant virus and 10% of new transmissions involve resistant or multi-resistant viruses. With the roll out of HIV therapy in developing countries, drug resistance will become a worldwide problem, while resistance development in non-subtype B strains of HIV (dominant in developing countries) is largely inferred from results obtained with subtype B viruses. Protease inhibitors (PI) have been a key factor in the success of HIV therapy, but as with all clinically used drugs resistance has been observed.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP6-2005-LIFESCIHEALTH-6
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

STREP - Specific Targeted Research Project

Coordinator

UNIVERSITÄTSKLINIKUM HEIDELBERG
EU contribution
No data
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Participants (7)

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