Objective
The project concerns the design, development and optimisation of an 'in vitro? system to replace the animal experimentation in pharmacology and toxicology on neural tissues and in particular on memory and learning. The ?in vitro? system will consist of a three-dimensional neural tissue, based on a hydrogel layer bearing neurons generated from mouse embryonic stem cells. The hydrogel layer will be interfaced with multielectrode arrays for electrical stimulation and recording purposes.
Our objective is to use ?in vitro? developed neural tissues instead of transgenic animals carrying memory and learning deficiencies and, for this reason, our system will be formed by mutated cell lines. Our approach will replace the use of transgenic animals or (at least) provide preliminary information at the tissue level to orient the design of the transgenic animals towards the optimal ones decreasing this way the number of animals that are currently created (and sacrificed) by trial-and-error methods.
In addition the system will be used in neurotoxicity tests to correlate measurements at sub-cellular, cellular and synaptic network levels as an integrated set with ?in vivo?-like effects on in vitro memory/learning, setting the methodological basis for the design of complementary in vitro tests needed to predict human hazards.
The partners of the ARTEMIS constitute an effective consortium that includes experimental and computational biomedical and biomaterial specialists along with animal experiments labs and standards professionals in this field. The SMEs participation in the ARTEMIS project is significant due both to the importance of their contribution at scientific and technological level but also to the important benefits they will obtain from the outcomes of the project.'
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine toxicology
- medical and health sciences basic medicine pharmacology and pharmacy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.