Objective
It is widely accepted that rapid, cost-effective diagnosis of high sensitivity and specificity is a pre-requisite for the prevention and control of tuberculosis, a global disease in humans killing more than 3 million people annually. Methods and devices currently in use do not meet these requirements. New strategies are urgently needed for combating the problems of TB diagnosis.We have recently developed first generation detection tests using a novel, high speed device for quantitative measurement of antigens in sputum and urine of tuberculosis (TB) patients. The device also enables simultaneous measurement of antigens and antibodies within 20 minutes. The main objectives of this proposal are 1. to identify novel antigens using genomic and proteomic approaches, 2. to purify sufficient quantities of antigens and raise antibodies 3. optimise immobilisation conditions for the specific antigens and antibodies on different carriers, 3. manufacture and evaluate different fast tests using approximately 6000 clinical specimens (sputum, saliva, serum, urine) from TB patients at study sites in Asia, Africa, America and Europe. In our opinion, such tests and devices would be a major breakthrough in the early diagnosis and prevention of tuberculosis. In this project, the Coordinator (LIONEX, an SME) in co-operation with a WHO center and lung hospital in Germany and additional expert scientists from low-resource, TB-endemic countries (India, Turkey, Nigeria, Mexico) shall evaluate the clinical potential of antigen and antibody detection using the high speed, cost-effective POC tests, with which results can be obtained on site within 20 min. Finally, the project also aims at developing TB-HIV dual antibody detection POC Fast tests. The outcome of this project shall lead to new diagnostic tests which will be inexpensive and fast providing results within 15-20 minutes, will be performed on site and shall not require any complicated or expensive instrument.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-7
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BRAUNSCHWEIG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.