Objective
The omics revolution of recent years has led to an explosion of data. This information however is currently difficult to integrate and makes improving knowledge on the complexities of biological events a difficult task. A major constraint for small and medium enterprises (SMEs) in the biotechnology field of data integration is the lack of appropriate tools for generation and analyses of dynamic models. BioBridge proposes to tackle this problem with the production of the Biobridge portal, an environment,where: 1)structured databases including genomic, proteomic, metabolomic information of metabolic pathways affected by disease will be 2)integrated to reconstruct the underlying metabolic pathways which, in turn, will enter in 3)a simulation environment for simultaneous analysis of multilevel data able to improve existing knowledge on complex metabolic processes.
The consortium brings together selected SMEs with complementary skills in the domains of semantic interoperability, heterogeneous data integration and simulation technologies to develop innovative tools to facilitate the interplay between omics data and clinical information.Synergies are ensured between SMEs and academic teams, as well as product quality assurance through generation of experimental data for model refinement and validation.Thus BioBridge academics and SMEs together facilitate a translational analysis of the test case: nitrosoredox imbalance of the cardiovascular system.The nitrosoredox disequilibrium governs O2 transport O2 utilization mismatching at tissue level in highly prevalent chronic disorders (chronic heart failure, chronic obstructive pulmonary disease and diabetes). It has been identified as a common pathway leading to the systemic effects, which are associated with poor prognosis and high use of healthcare resources.The produced simulation tools may help to identify appropriate biomarkers for non-invasive monitoring and offer a new state-of-the-art tool for clinicians.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences data science data mining
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences health sciences nutrition
- medical and health sciences clinical medicine cardiology
- natural sciences computer and information sciences software software applications simulation software
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.