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Content archived on 2024-05-29

Dynamic connectivity in the Motor System during tasks in health and disease

Objective

The voluntary movement planning process involves highly complicated dynamic interactions between several key brain structures most notably the cerebral cortex, basal ganglia and cerebellum. Knowing how these interactions are affected by learning and by neurological diseases can both advance basic brain research and lead to development of new diagnostics and treatment strategies. In the recent years the group of Prof. Peter Brown has studied movement preparation by recording intracranially from patients during and following deep brain stimulation surgery. Relations were found between neural oscillations and the ability to generate or suppress voluntary movements.

However, is not clear what the underlying neural mechanisms for these oscillations are and how these mechanisms are affected by learning. The group of Prof. Karl Friston has recently developed a new data analysis approach called Dynamic Causal Modelling (DCM). DCM makes it possible to naturally integrate data recorded with different neuroimaging methods and translate the results into biologically relevant terms. The proposed project is collaboration between the two groups with the purpose of extending the DCM approach to analysis of intracranially recorded data and combining these data with non-invasive magneto- or electro- encephalographic recordings.

As a result, the group of Prof. Brown and a network of collaborating labs all over Europe will be provided with a novel and highly promising data analysis tool. On the other hand, the DCM approach will be tested on a system with non-trivial dynamic interactions, which has already been extensively studied on different levels, making it possible to validate the findings. The project will be carried out by a highly qualified postdoctoral fellow undertaking t ransnational mobility from Israel to the UK. This fellow will learn and develop both neurophysiological recording techniques in humans and highly advanced data analysis methods.

Fields of science (EuroSciVoc)

Keywords

Topic(s)

Call for proposal

FP6-2005-MOBILITY-5
See other projects for this call

Funding Scheme

EIF - Marie Curie actions-Intra-European Fellowships

Coordinator

INSTITUTE OF NEUROLOGY, UNIVERSITY COLLEGE LONDON
EU contribution
No data
Total cost
No data