Objective
Traumatic injury to the brain and spinal cord represents a devastating change in the lives of many individuals. In addition to preventative measures, there is a clear need for early neuroprotective treatment strategies to minimise the damage caused by the traumatic incidencts.
Two key aspect of discovering such new treatments are:
a) the identification of appropriate targets and
b) the use of predictive screening models.
With respect to (a),this can be investigated pharmacologically or by the use of molecular biological techniques. With respect to (b),initial studies should use an in vitro system in view of the three Rs (refine, reduce and replace) of animal research. In my laboratory, the hypothesis that compounds preventing the uptake and metabolism of endocannabinoids may be useful neuroprotective agents is being explored.
This requires an interdisplicinary approach, provided by collaborations with research groups both within and outside the EU. However, we currently lack two key techniques: a) organotypic cultures from adult rodent brain and spinal cord, in order to study potential neuroprotective agents in a relevant in vitro model, and b) siRNA, to reduce the activity of specific targets in the organotypic cultures when selective inhibitors have not been identified. This proposal uses a time line whereby two experienced researchers are recruited sequentially in order to teach us these techniques. The researchers will participate in the training of designated PhD students and laboratory assistants to ensure effective transfer of knowledge.
The techniques will be used initially to determine whether modulation of the endocannabioid system is a potential treatment strategy for limitation of damage after trauma. The techniques, however, are generic and can in combination be applied to evaluate other potential targets at an early stage. This will greatly strengthen our competitiveness and ability to attract talented researchers to a less favoured region of LFRs of EU.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences basic medicine neurology stroke
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-3
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
UMEA
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.