Objective
Women are twice as likely as men to experience depression in their lives, yet the reasons for this sex difference in mental illness are unknown. Recently it has been proposed that neurogenesis, the production of new neurons in the adult brain is involved i n the expression of major depression, although the studies have only been conducted in males. In this project, the research fellow will examine how stress and learning alter the survival of newly generated neurons in the female versus the male hippocampus. Recent studies from the host outgoing institution have shown that learning increased the survival of new neurons. However, exposure to uncontrollable stressful experience dramatically impairs learning in females. Therefore, we propose that uncontrollable but not controllable stress will reduce learning in females and prevent the increase in cell survival, whereas exposure to the stressful event will have no effect on cell survival in males. We further propose that these adverse effects in females can be prevented by chronic treatment with the common antidepressant fluoxetine. Finally, we will determine whether the presence of female sex hormones, estrogen and progesterone are necessary and will also correlate changes in neurogenesis with serotonergic activity/ 5-HT1A receptor expression in the hippocampus. The results from these experiments will provide critical information about how females respond to stress and hopefully will lead to new and improved treatment strategies for women suffering from depression. It is envisaged, that this project will permit the enhancement of the existing expertise, the researcher's transnational mobility and training and the establishment of international cooperation. Thus, it will contribute to European excellence and competitiveness.
Fields of science (EuroSciVoc)
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-6
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
ATHENS
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.