Objective
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a significant health concern in the developed world, and the number of affected individuals is on the rise in both Europe and the USA. The cause of IBD is not known; however, the intestinal bacterial flora and an inappropriate ("pathogenic") immune response to these bacteria are believed to contribute to the onset of disease. Despite available treatments for humans with IBD (medications, nutritional therapies, and surgery) there are many patients for whom these therapies are not effective. Thus, increased knowledge of the interactions between intestinal bacteria and the immune system in individuals with and without disease is of utmost importance as such information m ay aid in the development of new therapies for IBD.
This project aims to identify the mechanisms by which bacteria trigger intestinal inflammation in disease-susceptible individuals. Using an experimental model of IBD involving infection with Helicobacter hepaticus, we will focus on the initial encounter between bacteria and cells of the innate immune system and examine how these interactions lead to the development of a pathogenic T cell response and subsequently disease. The two specific objectives of this proposal are to explore the mechanism by which H. hepaticus activates cells of the innate immune system, and to identify the anatomical location where priming of disease-inducing T cells occurs. These objectives will be achieved using cellular immunology methods and a newly developed transgenic mouse model incorporating the T cell receptor of a disease-inducing T cell clone directed against a defined protein of H. hepaticus.
The proposed project is likely to provide new insights into the mechanisms underlying the induction and regulation of intestinal inflammation, and support from the European Commission will actively help establish the applicant's research program in the EU.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- medical and health sciences clinical medicine gastroenterology inflammatory bowel disease
- medical and health sciences basic medicine immunology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
YORK
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.