Objective Vertebrate development is orchestrated by the coordinated deployment of multiple and diverse programs of cell commitment and differentiation. One of the fundamental questions in this process is how a discrete number of transcriptional programs and extracellular cues combine to produce the enormous cellular complexity that characterizes vertebrate organisms. This research aims at uncovering the general principles of how cellular diversity is created in the sensory nervous system.We aim to determine: 1/ the transcriptional programs directing the commitment and differentiation of different types of sensory neurons and 2/ how, when and where different types of sensory neurons are committed by genetic tracing. The proposed research takes advantage of multidisciplinary approaches including model systems and methods such as rapid screening of gene function in the chick, a boundary cap neural stem cell culture system, and advanced mouse genetics for revealing gene function and for lineage tracing. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesgeneticsmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicineneurology Keywords Cell Type Specification Neural Crest Sensory System Stem Cells Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Call for proposal FP6-2005-MOBILITY-5 See other projects for this call Funding Scheme EIF - Marie Curie actions-Intra-European Fellowships Coordinator KAROLINSKA INSTITUTET Address Nobels väg 5 Stockholm Sweden See on map Links Website Opens in new window EU contribution € 0,00
