Objective
Heart valve malformations occur in 2-3% of the population, leading to significant morbidity and mortality. However, very little is known about valve formation at the molecular level. During valve development, NFATc1 proteins are active and located in the nuclei of endocardial cells. In this research project, I propose to study the upstream regulator(s) of endocardial NFATc1 activity required for heart valve elongation and remodelling. My long-term career goal is to elucidate the molecular mechanisms underlying heart valve development and to recapitulate these developmental processes for regenerative purposes. Preliminary studies suggest the presence of an upstream signal(s) to maintain the activity of NFATc1 during heart valve development.
This project is ai med to shed light on two hypothesis:
(1) a soluble myocardial signal(s) controls the activation of NFATc1 in the endocardium and
(2) such a signal(s) is regulated by calcineurin/NFAT signaling in the myocardium.
Specific aims of this project will be achieved using cutting-edge technologies in gene targeting, imaging techniques, cell culture and mouse embryological studies. I will use NFATc (c1-c4) and calcineurin knockout mice, Cre-lox recombination and different reporter lines to study NFATc1 function in vivo. This fellowship will provide me with the opportunity to develop a research project with great clinical relevance in two outstanding centres aimed for cardiovascular research: CCSR (Stanford University) and CNIC (Spain). My training programme will also include acquisition of complementary skills in management, ethics, communication, Given the CNIC's innovative environment and robust training program, critical mass of researchers and its close ties to some of the best basic science departments in the world, the CNIC will provide a unique environment for the development of my career as an independent investigator in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- natural sciences biological sciences biochemistry biomolecules proteins
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-6
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.