Objective
This project concerns the vascular physiopathology of the receptor-ion channel complex Polycystin1/Polycystin2 (PC1/PC2). Mutations in the PC genes PKD1 and PKD2 provoke autosomal dominant polycystic kidney disease (ADPKD). This is one of the most frequent inherited kidney diseases with a prevalence of about 1/1000. Arterial hypertension, cerebral aneurysms and prolapse of the mitral valve are also associated with ADPKD.
The molecular and cellular mechanisms linking PC with the cardio-vascular phenotype are still unknown. Dr. Eric Honore (CNRS, Valbonne) has been working on the molecular physiology of ion channels since several years. His laboratory is currently developing complementary strategies of molecular cloning, proteomic analysis, functional reconstitution, electrophysiology, calcium imaging and transgenics for the study of mechano-sensitive ion channels. We will examine the role of the PC1/PC2 molecular complex in the regulation of vascular calcium homeostasis.
Specifically, we will study ion channel activity of PC at the level of both the plasma membrane and the endoplasmic reticulum of vascular smooth muscle and endothelial cells. I will use my expertise in protein purification and functional reconstitution into artificial bilayers to understand the molecular basis of PC mechano-sensitivity. This study will be useful to address the role of PC in vascular physiology. Moreover, these results will provide information concerning the genesis of cerebral aneurysms and arterial hypertension associated with ADPKD.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine physiology homeostasis
- medical and health sciences clinical medicine nephrology kidney diseases
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.