Objective
The vertebrate central nervous system (CNS) is composed by a large number of interconnected neurons distributed in different regions and with diverse functions. Recently, it was demonstrated that newly born neurons are generated in the adult mammalian brain that can be functionally integrated into already existing circuits. Also in fishes a peripheral structure of the retina, called ciliary marginal zone (CMZ), retains a reservoir of active stem cells that contributes to the life-long growth of the eye by adding newly born neurons, making this animal model suitable for the analysis of post-mitotic neuron generation and cell fate determination at post-embryonic stages.
The main focus of this proposed project is to understand how neurons can be generated and integrated into existing organs using the CMZ of medaka (Oryzias latipes) as a model system. The transparency of fish embryos and larvae will permit 4D microscopy observation of fluorescent molecular markers to analyse in vivo temporal aspects of the process. I will also take advantage of the bean-shaped eye (bns) mutant in which CMZ retain stem cell properties whereas differentiation is severely impaired, being an ideal mutant to study the molecular requirements for postembryonic neurogenesis.
This genetic approach will allow characterizing CMZ-growth mutants and identifying new molecules involved in its regulation, hopefully contributing to the understanding of molecular mechanisms that control neurogenesis after embryonic development. To manipulate the genetic cascades that regulate neurogenesis at post-embryonic stages is of great interest regarding the possibility to establish protocols for the treatment of neurodegenerative disorders in humans. I will profoundly benefit from learning advanced techniques such as 4D microscopy in an expertise lab; the possibility to perform this project in one of the leading European Institutes will be an invaluable step on my scientific career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences developmental biology
- medical and health sciences clinical medicine ophthalmology
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine transplantation
- medical and health sciences clinical medicine embryology
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.