Objective
Many of Nature and apos;s most potent molecules have within their structure, a cyclic arrangement of atoms. Similarly, in the chemical industries, cyclic structural motifs are present in many products. In fact, cyclic organic molecules have an important role to play in all areas of life. The development of new ways to construct such molecules in a controlled and selective manner is understandably a key area of chemistry. We will build on recent discoveries from the Manchester group that show a single, acyclic starting material can be `directed down a number of different cyclization pathways by simply changing the alcohol co-solvent used in reactions with the popular reducing agent samarium iodide. These new, stereoselective cyclization reactions allow quick access to a range of molecular architectures found in targets of biological significance that are otherwise not easily made.
The project will involve work in several chemical disciplines including, organic synthesis, inorganic/organometallic chemistry, physical organic, and medicinal chemistry. The specific objectives are: - prepare N-heterocyclic frameworks by the cyclization of lactam substrates - assess the generality of the co-solvent `directing phenomenon - develop an asymmetric synthesis of new, cyclic a-amino acids - carry out a `directed, asymmetric synthesis of the core of the biologically active natural product, stolonidiol New organic reactions that allow drugs and other active agents to be constructed rapidly save time and other resources.
The principle of making many different products from a common starting material is also economically very attractive. In addition, the work will provide new building-blocks for use in biology and medicine, thus assisting the fight against disease and illness. The project will provide diverse, `tailored training for an excellent European researcher and will lead to scientific results that will enhance the profile of European research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry organic reactions
- medical and health sciences basic medicine medicinal chemistry
- natural sciences chemical sciences inorganic chemistry organometallic chemistry
- natural sciences biological sciences biochemistry biomolecules
- natural sciences chemical sciences organic chemistry alcohols
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MANCHESTER
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.