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Development a new biocoating multi-layered polyelectrolyte film with incorporated drug-loaded liposomes

Final Activity Report Summary - BIOCOATING (Development a new biocoating multilayered polyelectrolyte film with incorporated drug-loaded liposomes)

The main aim of the project was to develop a novel biocoating for controlled drug delivery, e.g. manipulated by external stimuli. This was planned to be achieved by developing stimuli-sensitive polymer films with embedded biomacromolecules or carriers, such as liposomes. The project was implemented according to the objectives in the original proposal. The summary of the performed work as a response to the three main objectives in the original proposal is given below.

1. objective 1, preparation of drug reservoirs, i.e. liposomes with controlled permeability. The stabilisation of the liposomes by polymer surface coating was introduced in the work as an efficient method to avoid vesicle rupture under contact with a solid surface. The physical chemistry of the polymer liposome stabilisation was considered.
2. objective 2, immobilisation of the liposomes on a solid surface. In the second step a new method to introduce the polymer stabilised liposomes in the biocompatible film was developed. Physico-chemical aspects of the vesicle embedding were investigated and a way to predict liposome stabilisation by polyelectrolyte coating was elaborated, showing high potential to use this system as temperature-responsible biocoating.
3. objective 3, development of approaches for controlled release of drugs from immobilised liposomes. We showed film functionalisation with a variety of bioactive nanomaterials and micromaterials, such as biomacromolecules like deoxyribonucleic acid (DNA), metal nanoparticles and polymer microcapsules). A concept of infra-red light (IR) remote release of film-immobilised materials as well as liposomes was also elaborated.

The achievements of the project clearly demonstrated a high promise to use the developed stimuli-sensitive films for drug delivery applications. IR-light was a non-invasive stimulus and its use in medicine undoubtedly opened new perspectives for delivery on demand which could make medical treatment easier, efficient and more convenient for a patient.

Finally, six articles in peer-reviewed scientific journals and two book sections were published based on the results of the project activity. One European patent was pending by the time of the project completion, while two manuscripts were in preparation.