Objective
Pharmaceutical compounds are considered emerging contaminants and possible candidates for the introduction into the Water Framework Directive list of priority substances (2000/60/EC). They are continuously introduced into sewage waters, and as a result, found in surface, ground and drinking waters.
Even though they have high transformation and removal rates, they may display chronic exposure characteristics due to their continuous input, as their elimination during wastewater treatment is rather low. However, there is a lack of knowledge about long-term effects in non-target organisms as well as for human health.
Four of the most important groups of pharmaceuticals found in aquatic environments are antibiotics, analgesics, anti-epileptics and beta-blockers. Toxicity testing has indicated a relatively low acute toxicity to fish species, but no information is available on possible sublethal effects, which may reduce fitness or reproductive potential and thence have knock-on ecological effects.
The objective of this study is to determine the sublethal effects of four relevant model pharmaceutical compounds on the transcriptome and proteome of Atlantic salmon. Individuals will be exposed to environmental concentrations of the selected compounds.
Changes in gene or protein expression will be analysed using an Atlantic salmon cDNA microarray and 2-dimensional-difference gel electrophoresis respectively, and compared with classical toxicity endpoints such as histopathology.
The integration of functional genomics technologies with classical methods in toxicology enables comparison of mechanisms, and early detection and prediction of toxicity and may provide early, rapid, sensitive and specific biomarkers of effects.
This project addresses directly EU policies related to the risk of chemicals to the functioning of aquatic ecosystems and to human health such as the 6th Environmental Action Plan, the Water Framework Directive, and the Directive 91/271/EEC among others.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences zoology ichthyology
- natural sciences earth and related environmental sciences hydrology limnology
- natural sciences chemical sciences electrochemistry electrophoresis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
STIRLING
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.