Objective
One of the key features of the nervous system is that every brain area consists of a large variety of cell types defined either by their genetic profile, anatomy or physiology. It is widely believed and in some cases experimentally demonstrated that different cell types form well-defined microcircuits.
One of the major challenges of neuroscience is to understand the structure and function of these circuits. The mouse retina provides an exceptional opportunity to reveal the structure and function of microcircuits.
First, the input to the retina, the dynamically changing light pattern is well defined and can be experimentally manipulated. Second, it is possible to record the activity of most cell types during light stimulation from isolated retinas. Third, through standard genetic manipulations different cell types can be labelled with fluorescent markers allowing the identification of these cells in living retinas.
The team's goal is to elucidate the structure and function of genetically identified microcircuits in the mouse retina, where approximately 52 cell types are organized into a dozen neural circuits. The team combines different biological disciplines to reach this goal.
Transgenic technologies are used to label retinal cell types, viral tracing methods are used to "light up" the connections of the labelled cell classes and electrophysiology combined with two-photon microscopy is used to record the activity of labelled cells during stimulation of the retina with light patterns.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences microbiology virology
- medical and health sciences medical biotechnology genetic engineering
- medical and health sciences clinical medicine ophthalmology
- medical and health sciences basic medicine physiology
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-8
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BASEL
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.