Objective
Yong-Qing Yang is a highly talented young chemist in the final year of her PhD at Shanghai Institute of Organic Chemistry (SIOC), Chinese Acad. Sciences, a world-leading Science & Technology Institution.
She has already demonstrated significant potential to be a leading researcher through the important work that she has published in leading International chemistry journals. Her expertise in synthesis provides her with a strong platform of practical skills to complement those in chemical biology of Dr Thomas- group at Nottingham Univ. in the proposed multidisciplinary research.
This project aims to develop tools to selectively modify ONLY a single protein in a cell with a functionalised biotin, and then to use this versatile biotin 'handle' to conduct further 'bio-orthogonal' chemistry (Staudinger ligation, 'click-chem') allowing the introduction of fluorescent, crosslinking or immobilisation tags ONLY onto the biotin analog. Using these tags transient protein-protein interactions and protein location in-vivo can be identified.
This will provide new fundamental proteomics information forming the basis for drug discovery as fits several FP6 objectives including 'Application of knowledge and technologies in the field of genomics and biotechnology for health: rational and accelerated development of new, safer, more effective drugs'. Training at Nottingham will involve Ms Yang obtaining new practical skills in biophysical and biochemical techniques.
She will then be in a strong position to act as a leader and female role model in interdisciplinary 'Chemical Biology' research in China. She will participate in the Nottingham Career Advancement program that covers managerial, IP protection and leadership skills courses for young researchers.
The biotin tools developed in Nottingham will be transferred back to China, and, through collaboration applied to identify the effect of traditional Chinese medicines at a molecular level using Western Medicinal Chemistry techniques.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences chemical sciences analytical chemistry calorimetry
- natural sciences chemical sciences organic chemistry amines
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
NOTTINGHAM
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.