Objective
The nociceptive system, from which pain emerges as a percept, may be viewed as a dual afferent sensory network whose peripheral inputs are conveyed by Ad- and C-fibres.
Human electrophysiological studies, using event-related brain potentials (ERP), as well as human neuroimaging studies, using functional magnetic resonance imaging (fMRI) and positron-emitting tomography, have shown that a nociceptive event elicits brain responses within an extensive cortical network, bilaterally involving secondary somatosensory, insular, and anterior cingulate cortices.
The respective involvement of these cortical responses to the perception of pain is quite largely unknown. A number of studies have pointed at the similarities between nociceptive evoked potentials and late evoked potentials, which may be elicited by a sensory stimulus regardless of its modality.
Determining whether all or part of the ERP and fMRI activity elicited by a nociceptive stimulus reflects brain processes truly specific of the nociceptive system constitutes the first objective of this research project.
Human electrophysiological studies have shown the existence of significant interactions between the central processing of Ad- and C-fibre nociceptive input but also between the central processing of nociceptive and non-nociceptive somatosensory input. Indeed, reproducible C-fibre ERPs appear to be recorded only if concurrent activation of Ad-nociceptors is avoided.
Similarly, reproducible Ad-fibre ERPs appear to be recorded only if concurrent activation o f non-nociceptive Aß-fibres is avoided. Better understanding the mechanisms which condition the triggering of nociception-related ERP and fMRI activity constitutes the second objective of the project.
By providing some insight as to the functional significance of ERP and fMRI correlates of nociception-related brain processes, this proposal may contribute to the development of novel diagnostic tools and therapeutic strategies for the treatment of pain.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OXFORD
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.