Final Activity Report Summary - CARDREG (Calcineurin isoforms in cardiac disease and regeneration)
In this project we have identified a particular molecule, called CnAbeta1, with strong regenerative properties. CnAbeta1 is naturally expressed in stem/progenitor cells and developing tissues. We have shown that increasing the expression of CnAbeta1 in skeletal muscle enhances its regeneration capacity, resolving inflammation faster and reducing the formation of a scar. In the heart, increased expression of CnAbeta1 prevents cardiac atrophy and, more importantly, it induces cardiac recovery after myocardial infarction. CnAbeta1 reduces inflammation and the formation of a scar and promotes the appearance of new cardiac myocytes, which contributes to the improvement in heart performance.