Objective
All stem cell populations are controlled by a number of intrinsic and external regulatory mechanisms that function in maintaining balance between stem cell self-renewal and commitment to differentiation.
Recent evidence also suggests that some cancers are controlled by a small population of tumour cells that exhibit stem cell like qualities (referred to as cancer stem cells) lending to the hypothesis that cancer is a disease of uncontrolled stem cell self-renewal. This proposal aims to elucidate how the transcription factors c-Myc, N-Myc and c-Jun interact with each other to control haematopoietic stem cell (HSC) fate.
We will induce the conditional deletion and over-expression of these genes in mouse adult HSCs and single/double mutant HSCs will be subsequently injected into lethally irradiated mice, quantified by limited dilution assays and the effects on the stem and progenitor cell pool and each of the haematopoietic lineages assessed by cell cycle analysis and FACS.
Particular focus will be placed on identifying how these proteins govern the molecular interaction between HSCs and their micro-environment (stem cell niche). An in depth knowledge of these mechanisms will be crucial in the development of conditions suitable for the in vitro expansion of adult HSC populations for clinical applications.
This project also aims to elucidate the role of the c-Myconcogene in an AP-1 driven chronic myeloid leukaemia (CML) model. We will over-express the c-Myconcogene in a JunB-derived CML mouse model to address the r ole of c-Myc in regulating the malignant expansion of leukaemic stem cells.
These data will provide insight into how signalling pathways governing normal stem cell homeostasis regulate tumour formation, thus allowing the development of novel treatments for the elimination of cancer cells.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology leukemia
- medical and health sciences clinical medicine embryology
- medical and health sciences basic medicine physiology homeostasis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
EPALINGES
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.