Objective
In eukaryotic organisms, essential processes such as RNA transcription, DNA replication and repair are dependent on chromatin structure. Chromatin modifying enzymes are critical for the dynamic regulation of chromatin structure during the cell cycle and the maintenance of proper cell function. The proposal is focused on the Saccharomyces cerevisiae Esa1 protein, a member of the conserved MYST family of histone acetyltransferases. Indeed, Esa1p is involved in very diverse processes such as transcriptional silencing and activation, and have critical roles in DNA damage repair, cell cycle control, and chromosomal and sub-nucleolar architecture. Yet, much remains to be learned about Esa1p genomic targets and interactions.
The aim of this project is to characterize the functional diversity of the MYST HAT Esa1p in DNA-dependent processes. Esa1p is known to regulate activation of transcription through chromatin acteylation within a multimeric complex called NuA4. We will ask whether Esa1p promotes silencing through this complex or another one, yet unidentified. At last, newly defined HAT activities that suppress esa1 mutants will be characterized and their function in DNA damage/repair explored.
The new skills and knowledge acquired during this training in a third country organisation will be transferred and applied to the pathogenic yeast Candida albicans. Indeed, knowledge on chromatin structure function in this species is limited. Most interestingly, various aspects of C. albicans biology are likely to be the subject of epigenetic regulation involving changes in chromatin structure. Thus, we will initiate the functional characterization of the ESA1 homologue in the biology and pathogenesis of C. albicans. This project will allow the applicant to gain a highly qualified training in world-class research institutions and to develop an independent research career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.