Objective
Rapid generation of morphological change has long puzzled biologists, as it is difficult to reconcile with the low frequency at which point mutations occur. In general, the mechanisms that underline the genesis of extreme diversity are unknown, but they ma y be relevant to many situations in the natural world (i.e. adaptive radiations). Here I propose the dog as a model for the study of such mechanisms: they have an extreme morphological diversity; their ancestor, the wolf, is still extant and available for comparison; and the genome has been recently sequenced and a large number of markers are available. I plan on studying two of the mechanisms that can contribute to the generation of diversity in dogs. Also, I would like to apply current knowledge on the do g genome to understand processes and forces acting on natural populations of wolves. Some studies have shown that recombination rates increase with stress level. I hypothesize that the change in life style in dogs compared to wolves may have resulted in higher recombination rates. As a consequence, new allele combinations have arisen providing the raw material for artificial selection to act upon. I will test this hypothesis by typing microsatellite markers with known locations in the sperm of dogs and wolves. Also, SINEs and tandem repeats can have effects on gene expression. I will study variability in SINEs and tandem repeats associated to genes with known function in dogs and wolves and try to correlate their diversity with phenotypic diversity in both species. In North American and European wolves I will compare coat colour gene sequences. Moving to a European Host Institution in accordance with my professional needs will contribute to the diversification of my competences and to my development as an independent researcher. Mobility of researchers is a key action for the developing of long lasting synergies and networks in Europe and, consequently, for boosting and structuring the European Research Area.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences evolutionary biology
- natural sciences biological sciences genetics nucleotides
- natural sciences biological sciences zoology mammalogy
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
UPPSALA
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.