Objective
In clinical chemistry, pharmaceutical research and biochemistry the precise and accurate quantification of proteins is critically important.
The invention of soft-ionization sources such as electrospray and MALDI, has introduced a revolution in protein characterisation owing to the rapid access to protein sequences. However, these techniques are far from yielding precise (1-2%) quantitative information on the proteins.
The vision of the project is to achieve a quantum leap in quantitative proteomics by improving its sensitivity and precision by at least one order of magnitude. To achieve this, a completely new concept of quantitative proteomics is proposed: heteroatom tags, ICP MS and isotope dilution analysis. The goal of the project is the specific labelling of proteins with heteroatom tags for accurate and precise protein quantification, and the development of the related analytical technology.
These tags should selectively react with particular amino acids or post-translational modification sites of proteins.
The most novel idea is a multi-tagging approach. Contrary to the current procedures, a mixture of tags specific for individual functional groups can be used and then all the information can be obtained in one analytical run. Precise protein quantification may become a diagnostic tool and applications in biomedical research may emerge. Profiling of e.g. phosphoproteins in body fluids or tissue homogenates may become of significance in differential diagnosis of cancer or other diseases and may be developed into a tool for individual therapy control. Consequently, a success of the project will have enormous impact on biochemical, clinical and pharmaceutical research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- social sciences political sciences political transitions revolutions
- natural sciences chemical sciences organic chemistry amines
- natural sciences chemical sciences analytical chemistry mass spectrometry
- natural sciences physical sciences optics laser physics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.