Objective
Asymmetric cell division generates two daughter cells that adopt different developmental fates and often differ in size. For example, a stem cell generates another stem cell and a daughter cell that gives rise to differentiated cells. This vital type of cell division occurs in a wide range of organisms, from bacteria and yeasts to plants and animals, and plays crucial roles during multicellular development.
Molecular mechanisms of asymmetric cell division have been studied in animal model systems, such as Drosophila and C.elegans but barely addressed in plants. However, mechanistic differences are to be expected between the two groups since plants and animals have evolved independently. Although post-embryonic development predominates in higher plants such as Arabidopsis, the basic body plan is established during embryogenesis and here, the very first asymmetric cell division is crucial for all subsequent development. The Arabidopsis zygote divides asymmetrically to give an apical and a basal daughter cell. These two cells differ in gene expression, cell size and cell division program, and give rise to different pattern elements of the embryo.
Gene expression studies indicate that already at the earliest stages of embryogenesis, specific transcription programs are initiated in single precursor cells of embryo pattern elements. Furthermore, recent findings on the directional movement of the plant signalling molecule auxin provide a unique association between individual cell polarity and the establishment of polarity at the tissue, organ and whole plant level.
The aim of this project is to characterize the asymmetric cell division of the zygote and the establishment of apical versus basal cell fate at the molecular level. Our objectives are to: (1) generate and analyze fluorescent molecular markers, (2) search for regulators of BDL expression, and (3) identify transcriptional profiles of apical and basal cell.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences developmental biology
- natural sciences biological sciences cell biology cell polarity
- medical and health sciences clinical medicine oncology skin cancer basal cells
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
TUEBINGEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.