Objective
Chronic Obstructive Pulmonary Disease (COPD) is a global health problem of pandemic proportion, and is expected to become a leading cause of morbidity and mortality worldwide within 15 years.
Furthermore, new evidence indicating that exposure to air pollutants increases the risk of developing the disease is shifting the perception of COPD as solemnly a smokers disease towards becoming a general health concern in urban areas. COPD is primarily an inflammatory disease of the peripheral airways.
However, in contrast to other chronic airway inflammatory diseases, e.g. asthma, treatment with inflammatory cascade inhibitors are largely ineffective in COPD. No efficacious treatments currently exist to prevent the inflammatory progression of COPD, which invariably leads to impaired lung function and premature death. The mechanisms underlying the disease progression are not well understood, yet very few resources have been allocated to the study of COPD.
The main objective of the proposed study is to identify lipid- and protein-mediators critical in the pathological mechanisms underlying COPD. In accordance with the 1st thematic priority of FP6, proteomics and bioinformatics technology will be utilized to combat major disease: Through the use of state-of-the-art proteomics and metabolomics methodology, alterations of the proteome and inflammatory mediators in response to the disease progression will be quantified. Furthermore, the use bioinformatics applications and pathway construction will aid in a global understanding of the cellular mechanisms underlying COPD.
The results from this project are expected to have major effects upon the field of inflammation-associated diseases and will potentially develop new diagnostic techniques for early stage lung disease, enabling clinicians to apply intervention at earlier stages, thereby greatly reducing the costs to society and saving lives. A secondary accomplishment may be identification of novel pharmaceutical targets for COPD.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine pneumology asthma
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences health sciences inflammatory diseases
- natural sciences chemical sciences inorganic chemistry inorganic compounds
- engineering and technology environmental engineering air pollution engineering
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.