Objective
Recent advances in functional neuro-imaging have included
- the development of sophisticated connectivity techniques to study factors impacting upon the connectivity between different neural regions at the same time point and with varying temporal delays and
- the recognition that fMRI can be used to study the neural correlates of individual differences in healthy participants, such as variations in trait anxiety and genetic variations resulting from common functional polymorphisms in genes influencing neurotransmission.
The current proposal brings together these advances by using recent connectivity techniques to study the interaction between attentional and emotional networks and to address how differing task demands, individual anxiety levels and genetic factors influence patterns of connectivity between the neural regions that comprise these networks.
Specifically, the proposed work will test predictions derived from current models of attention and cognitive control and examine factors determining the connectivity between neural regions implicated in the control of task-related behaviour (in particular lateral prefrontal cortex and anterior cingulate cortex) and the detection of emotionally salient stimuli (especially the amygdala). In particular, the extent to which connectivity patterns vary with individuals anxiety levels and with COMT val 158 met and 5HTT-LPR genotypes will be addressed.
It is predicted that COMT val 158 met genotype through its influence on prefrontal dopamine will particularly impact on activity within the network of cortical regions implicated in cognitive control while the 5HTT-LPR genotype through its impact on serotonin levels will particularly influence a subcortical network focused on the amygdala and involved in the detection of emotionally salient stimuli. Anxiety is expected to modulate both networks with trait and state anxiety having differential effects upon each.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences artificial intelligence computational intelligence
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.