Objective
The aim of the project is to understand, quantify and model the influence of protein crowding in membranes on molecular mobility and interactions of membrane proteins and ultimately on cellular processes in particular signalling. In cellular membranes proteins occupy almost half of the available surface.
Obviously, this high total concentration of macromolecules within the membrane will influence processes in the membrane, even while the concentration of proteins involved in a particular process itself is low. Phenomenological data from animal models showed that signalling kinetics and sensitivity in the visual process, thus likely in G-protein coupled receptor (GPCR) signalling in general is strongly depending on the membrane-protein concentration.
However, t he influence of macromolecular crowding on interaction kinetics and equilibria has not been studied experimentally in membranes so far. An in vitro system will be established, in order to monitor how protein-protein interactions in membranes are effected by increasing concentrations of proteins in the membrane. As a read out, state of the art single-molecule fluorescence techniques will be used.
Finally, the findings will be related to data obtained in living cells, establishing the relevance of macromolecular crowding in membranes for biological systems and GPCRs specifically.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CH B3 494 LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.