Final Activity Report Summary - MeStells (Phenotypic differentiation of mesenchymal progenitor cells within differential inflammatory environments)
The field of regenerative medicine and tissue engineering is rapidly emerging and aims at achieving the regeneration of tissues and organs for the treatment of disease and injury. One major concept in this field is the surgical implantation of cells, either from the patient or from another donor, along with the simultaneous implantation of a custom polymer scaffold which is designed to repair the function of the injured tissue and induce its regeneration. However, the fate of these implanted cells is often uncontrolled and generally unknown. In addition, cells from the patient penetrating the implant are anticipated to react to the implant. The aim of the present study was to understand how different inflammatory responses controlled the development of these implanted cells, including their proliferation and differentiation.