Objective
A multi-technique multi-disciplinary research programme is proposed addressing analysis and selective recognition of biomedical materials and cells. The research will address two aspects in the analysis of biological samples, exploiting a combination of Raman spectroscopy, SNOM and confocal microscopy:
- the distinction and characterisation of micro-organisms (bacteria) for rapid turn-around analysis of infectious problems; and
- the investigation of IL-13 action on cells (exemplary for immunology research at and below cell dimensions).
The first topic entails research on micro-organisms, with the aim of rapid characterisation / identification of micro-organisms / microbial pathogens (e.g. multi-resistant strains of Staphylococcus aureus) and their sub-strains; this would help in the diagnosis of latent or new infections e.g. after surgery, and rapid response to and management of infection. Any ideal analysis technique should require minimal sample preparation, permit the automatic analysis of serial samples, allow their rapid characterisation against a stable database, would be easy to use and would be operated under computer control.
This study constitutes a development research programme to meet the aforementioned analysis criteria, and to establish sample preparation procedures compatible to those of other, established analysis methods. Research on IL-13 by J.M. Hopkins group (Medical School, University of Swansea) has recently identified a genetic polymorphism, linked with asthma, which results in an amino acid change in IL-13. The functional consequences of this are unclear, but modelling suggests that the change in sequence alters the differential affinity of IL-13 for specific receptors. We will undertake proof-of-principle experiments, using nm-scale NSOM techniques, to confirm that this change in sequence does indeed alter the affinity of the ligand for its various receptors. Time permitting the study will be extended to in vivo systems.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine pneumology asthma
- medical and health sciences clinical medicine surgery
- medical and health sciences basic medicine immunology
- natural sciences physical sciences optics microscopy confocal microscopy
- natural sciences physical sciences optics spectroscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SWANSEA
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.