Objective
Micro-organisms perceive, transduce and respond to a complex array of signals and stimuli, in both pathogenic interactions with hosts and during survival under stressful environmental conditions. Studying these interactions and responses requires the application of a multidisciplinary systems microbiology based strategy that considers external signals and host/community interactions as well as internal pathways of signal transduction (ST) and gene expression.
This project aims to acquire new expertise that will facilitate an interdisciplinary approach to understanding and manipulating these ST pathways. Firstly this will involve the use of the zebrafish as an alternative animal model to allow the in vivo study of these pathways in pathogenic bacteria and fungi; thereby increasing our understanding of how pathogenic microbes sense and respond to environmental signals, particularly those involved in triggering expression of virulence genes.
This system will facilitate the high throughput pathogenic screening of target genes in mutants and the use of in-situ imaging, to allow for rapid, non-invasive and real time analysis of in vivo gene expression. Secondly, it will involve the use of metagenomic expertise and novel heterologous expression systems, which will be used in high throughput screens; to isolate and identify novel bioactive compounds of pharmacogenomic relevance, that may modulate these ST pathways and influence survival or virulence in human hosts.
This ToK will be achieved by seconding 2 personnel from UCC to partner institutions, and by recruiting 7 (2 MER and 5 ER) experienced researchers with relevant expertise. These researchers will work on specific research projects and undertake designated activities to ensure that the acquired knowledge gets transferred and embedded at the host institution. The knowledge acquired will complement existing expertise at the host and will facilitate research of the highest international standards to be sustained.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences microbiology mycology
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-3
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CORK
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.