Objective
The discovery of penicillin and the widespread use of antibiotics to control infectious disease has been one of the most important innovations of the 20th century. However during the last decades several available antibiotics became ineffective due to evolutionary changes in bacteria that allow them to survive these powerful drugs. Multi-drug resistance efflux transporters threaten to reverse the progress of treating infectious disease by extruding a wide range of drug and other cytotoxic compounds. These proteins are embedded in the cell membrane and their function is to bind and transport a broad range of substrate out of the cell. Yet high- resolution structures of multi-drug resistant proteins have been solved, however those examples do not provide enough information to describe thoroughly the mechanism of multi-drug resistance.
Also less are known about such a bacteria which are the causing the major problems in nosocomial infections. The major focus of this project is to clone, over-express, functionally characterize, purify, crystallize and solve the structure of MDR transporters of DMT (Drug Metabolite Transporter) and MOP (Mulitdrug/Oligosaccharidyl-lipid/Polysaccharide Flippase) without and/or with their ligands to provide additional insight into the mul tidrug resistance of Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa and Staphylococcus aureus. The structural information will provide a basis for developing new, more effective drugs to treat serious infections.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences health sciences infectious diseases
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance multidrug resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
Hungary
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.