Objective
It is proposed to develop and apply ultra-small volume analytical chemistry techniques to measure molecules important in single cell neurochemistry and neurobiology. The importance of this work to the scientific community lies in that it defines the limits for measurements in small biological environments and it provides a means to examine molecular mechanisms of neuronal function and dysfunction (ilness). Techniques using microelectrode electrochemistry will be used to measure release of transmitters from single cells. Separations with micrometer and nanometer inner diameter capillary electrophoresis will be used to measure neurochemicals in spatially localized regions of cells and organelles.
Mass spectrometry imaging with submicrometer resolution will be developed to measure and determine the function of lipid domains in cell membranes. It is my goal to unify these techniques and measurements to provide a comprehensive view of the location, function and importance of membrane lipids regulating communicatio n via exocytosis. In addition, we will relate this function to the role of exocytosis proteins in regulating the exocytosis event.
This project will involve new developments in each technique area and applied analytical chemistry for bioanalytical measurem ents in neurochemistry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences chemical sciences electrochemistry electrophoresis
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-10
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GÖTEBORG
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.