This proposal is designed to add value to the European science community by enhancing the research and training required to improve treatment for chronic kidney disease that is a major threat to health in Europe. If successful, it will enable Professor Rees, an internationally recognised renal immunologist from the UK to translocate to the Institute of Clinical Pathology at the Medical University of Vienna where he would establish a joint teaching and research program with Professor Kerjaschki, the outstanding renal pathologist and cell biologist who heads the Institute. The resulting partnership would exploit their complementary expertise to make the Institute into a world-class European centre for much needed renal research and research training. First, the proposal will enable Professor Rees to develop a research program in the Institute designed to characterise macrophages infiltrating the damaged kidney and exploit their ability to either cause injury or to promote tissue repair depending on how they are activated.
This will be used both, to develop macrophages as endogenous "biosensors" of disease activity in the kidney and to identify novel therapeutic targets. Second, he will organise an outstanding research training program that combines specific training in renal research with generic skills to facilitate researcher mobility throughout Europe. Finally, he will establish a series of international "Frontiers of Renal Immunology" meetings that will enhance research in this area.
The proposal will promote the wider aims of the Marie Curie action and should benefit European science by developing a new multidisciplinary research centre in a much needed area.
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