Objective
The proposed project is a continuation of the current Marie Curie Intra-European Fellowship project. In the project the role of cellular mechanics in the formation of cancer metastases will be studied. Metastasis, the formation of secondary tumours, is the most feared and least understood aspect of cancer.
Regarding the commonness of metastases formation, a detailed view on the process of metastases formation reports a very complicated cascade of processes. For a cancer cell to metastasize, it must first detach from the parent tumour. Then, cancer cells have to penetrate tissues that provide only micrometer large holes for cells to penetrate.
Usually, these cavities in tissues are much smaller than the size of a single cancer cell. Thus, cells have to deform strongly which may only be explained if these cells adapt their mechanical properties for tissue penetration. Numerous processes in the cells, like mitosis, intracellular traffic of organelles are mediated by cell mechanics, more closely by the cytoskeleton.
We have demonstrated that the naturally occurring sphingosylphosphorylcholine (SPC), which occurs more abundantly in metastasized cancer cells and lysophosphatidic acid (LPA) modify the cytoskeleton, thus the mechanical properties of the cells. In the proposed project we will further study the mechanical properties of cells extending the selection of biochemical treatment, not only on fixed and stained cells, but also on living, fluorescently transfected cell lineages.
We want to analyse quantitatively the contribution of the various cytoskeleton filaments to the mechanical properties of the cells and draw clinical consequences regarding the formation of metastases from cancer tissues. We are aiming to a truly interdisciplinary research project which involves biochemistry (bioactive lipids), biophysics (imaging and mechanical measurements) and medicine (clinical relevance).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences biophysics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BUDAPEST
Hungary
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.