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Content archived on 2024-06-25

Structure-activity relationships leading experts in mutagenicity and carcinogenicity

Objective

The concept of a relationship between the structure and the toxic activity of chemical mutagens and carcinogens has been widely investigated. Structure-activity concepts have also been exploited to make safer chemicals. Whereas for academic purposes even studies based on biased data sets may provide useful information, the extensive regulatory use of (Q)SARs foreseen by e.g. REACH requires that the models fulfill severe quality criteria. Unfortunately, this ideal situation is not a common occurrence in toxicology. This proposal is aimed at organizing a debate among, and a Workshop of leading experts to critically review the situation of in the field of the (Q)SARs for mutagenicity and carcinogenicity, and to provide indications on hot topics issues to be further investigated. SCARLET is multidisciplinary and multisectorial. Regulators, scientists, problem holders, animal welfare experts, citizen organizations, and chemical industry will participate. Target is 40 participants; registration will be free to reach a wider participation. 6 fellowships will be given to young researchers. The workshop will be useful to cut barriers between scientific and societal areas. SCARLET will discuss an architecture to compare and integrate individual studies. Coordinators of EC projects will be invited, so that their results will be disseminated, providing a high resonance to the European research. This will also avoid repetition of studies, making optimal use of public money and identifying synergisms. Their EC projects will be a way to exploit recommendations from the workshop. The verifiable results will be the workshop, the internet site, a list of software and databases, the report with recommendations for use of computer-based methods in carcinogenicity, mutagenicity and genotoxicity. A paper summarizing the discussion at the workshop will be submitted to a scientific journal.

Fields of science (EuroSciVoc)

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP6-2005-SSP-5-A
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

SSA - Specific Support Action

Coordinator

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
EU contribution
No data
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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Participants (3)

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