Skip to main content

Avian influenza: impact of virus-host interactions on pathogenesis and ecology

Objective

Highly pathogenic avian influenza viruses (HPAIV) have acquired the unprecedented and alarming capability to infect humans. By establishing a permanent ecological niche in wild birds, HPAIV will pose a continuous risk for poultry and fatal human infections, especially if these birds excrete HPAIV without showing any clinical signs of disease. These changes in the ecology of the disease and behaviour of the virus may create opportunities for a pandemic virus to emerge. Attempts to avoid or contain HPAIV outbreaks have been largely unsuccessful. This can be directly linked to our lack of fundamental knowledge. Therefore, it is essential to increase our knowledge of the ecology and pathology of avian influenza virus infections in poultry and other species.

Full understanding of the ecology and pathogenesis of HPAIV requires a multidisciplinary approach determining host-pathogen interactions and the role played by the host immune response. To this end, the FLUPATH consortium was established. FLUPATH is composed o f 13 partners, 6 of which are National Reference Laboratories for avian influenza. The consortium further includes 5 academic institutions and 2 institutions specialized in animal science and health.

The participants, with expertise in chicken genomics, micro-array technology, pathology, receptors, innate immunity and chicken immunology, will use multidisciplinary and complementary approaches to address key problems and unanswered questions with respect to the ecology and pathogenesis of avian influenza. FLU PATH will provide knowledge and tools for new strategies which will be tailored for the control and management of avian influenza at the European and International level. This will limit the impact of this disease on human health and losses to the poultry industry in terms of animals and economics. The accompanying reduction in animal slaughter, financial and economic losses will place a significantly lower demand on EU and member states' budgets.

Call for proposal

FP6-2005-SSP-5-B-INFLUENZA
See other projects for this call

Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK
Address
Costerweg 50
Wageningen
Netherlands

Participants (14)

AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS
France
Address
27-31 Avenue Du General De Gaulle
Maisons-alfort
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION AUSTRALIAN ANIMAL HEALTH LABORATORY
Australia
Address
5 Portarlington Rd
Geelong
ID-LELYSTAD, INSTITUUT VOOR DIERHOUDERIJ EN DIERGEZONDHEID BV
Netherlands
Address
Edelhertweg 15
Lelystad
INSTITUTE OF VIROLOGY AND IMMUNOPROPHYLAXIS
Switzerland
Address
Sensemattstrasse 293
Mittelhaeusern
ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLE VENEZIE
Italy
Address
Viale Dell'universita 10
Legnaro Padova
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
20 Park Crescent
London
PHILIPPS UNIVERSITAET MARBURG
Germany
Address
Biegenstrasse 10
Marburg
ROSLIN INSTITUTE (EDINBURGH)
United Kingdom
Address
Roslin
Roslin, Midlothian
STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Germany
Address
Buenteweg 2
Hannover
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
Address
The Authority For Research And Development, Edmont J. Safra Campus, Givat Ram
Jerusalem
THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS
United Kingdom
Address
Nobel House. 17 Smith Square
London
THE UNIVERSITY OF EDINBURGH
UNIVERSITEIT GENT
Belgium
Address
Sint-pietersnieuwstraat 25
Gent
UNIVERSITY OF UTRECHT
Netherlands
Address
Yalelaan 1
Utrecht