Objective
The possibility of improving the function of organs or structures damaged in numerous pathological scenarios by the use of cellular therapies is a true clinical reality. Stem cells isolated from adult tissues are one of the tools for this new therapeutic approach. Adipose Derived Stem Cells (ADSC) have shown multipotency in vitro (differentiation into fat, bone, cartilage, muscle). Several pre-clinical studies point to the use of ADSC in cell therapies.
Anal incontinence (AI) impacts severely the quality of life of sufferers, about 2-8% of the adult population. Injury to the pudendal nerve and/or to anal sphincter muscle from prior obstetric trauma is described as the primary risk factor to develop AI. The overall aim of this project is to develop a cell therapy for AI using ADSC in an animal model of anal sphincter deficiency.
We will develop a rat model of AI by simulated birth trauma (vaginal distension + episiotomy), and will characterize the structural and functional changes of the anal sphincter by in vitro, in vivo and ex vivo studies. Then we will test the effect of cells injected in the anal sphincter in the structural and functional restoration of the anal sphincter, comparing multipotent, undifferentiated ADSC with cells differentiated into a myogenic lineage.
This project is relevant to the objectives of the Human Resources and Mobility Work Programme. This project will allow the return of a first-class European researcher back into Europe and transfer the knowledge acquired in his last eight years of research in USA, effectively reversing and cancelling the European brain drain. The applicant will join a PRO, the Cell Therapy and Regenerative Unit of the Autonoma University of Madrid, which was established in 2004 through collaboration with a Spanish SME, Cellerix.
Thus, this project will benefit the applicant's career in the prospects of durable and stable professional integration and will improve the collaborative research between PROs and SMEs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences histology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.