Objective
Within most olfactory systems, each neuron chooses to express only one specific odorant receptor out of a vast number of receptor genes. Understanding this complex process will lead to an increased knowledge not only on how the olfactory system is generated, but also provide a deeper insight into how cellular diversity is established in the human brain.
The main objectives of this proposal are to genetically and molecularly address:
- How is odorant receptor choice regulated at a transcriptional level?
- What are the factors, DNA-sites and regulatory processes involved?
The strategies for answering these questions are:
- To identify molecules that specify odorant receptor choice, a work which we have initiated using a novel transgenic RNAi screen in Drosophila. The initial screen has identified 212 candidate genes that effect odorant receptor expression.
- To perform an extensive phenotypic characterization followed by a more detailed analysis of a few selected genes, with the aim of further addressing specifically the molecular genetic interactions between the identified regulators.
- To explore how conserved these novel findings might be.
To this end, I plan to conduct parallel studies in vertebrate systems, using my previous acquired expertise in the mouse olfactory system. The proposed project will be beneficial at multiple levels:
- It will link multiple aspects of development that have been unconnected in the drosophila olfactory community.
- It will reveal novel genes and generate novel tools for addressing questions in other fields: epigenetics, cell signalling, stem cell research etc.
- It will strengthen both the olfactory and cell fate research fields in Europe.
- It will increase the scientific collaboration within Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences cell biology cell signaling
- agricultural sciences agriculture, forestry, and fisheries agriculture horticulture fruit growing
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences biological sciences genetics epigenetics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LINKÖPING
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.