Objective
Cell migration is a complex process that is central to many aspects of medicine and biological research: embryo development, tumour development (invasiveness and vascularization), and nerve regeneration after injury and stem cell migration. Migrating cells heavily rely on their ability to adhere to and extract information from extracellular molecules. For this purpose, they extend thin protrusions (filopodia) that probe the environment ahead of the cell. Due to fixation artefacts, these very thin and motile structures have proved difficult to analyse. Recent live cell imaging techniques offer new tools to elucidate how they form and understand their function. Integrins are transmembrane receptors of the extracellular matrix and regulate adhesion and migration by relaying external signals to the cytoskeleton. In neurons, integrins are also involved in several aspects of axon growth and guidance. Myosin-X (Myo10) was recently identified as an integrin-binding partner. Myo10 is a unique motor protein in that it not only binds to actin, but it also interacts with microtubules and several signalling molecules that are heavily involved in cell migration. Myo10 is found at the tip of filopodia and it influences their length and number. Interestingly, Myo10 is strongly expressed in neurons at the growth cone, the sensing tip of axons.
This project is aimed at answering the following questions:
- What role does Myo10 play in filopodia elongation? The implication of a possible vesicle docking and delivery function of Myo10 and the involvement of integrins will be assessed.
- What role does Myo10 play in axon growth and guidance? Manipulation of Myo10 expression and its binding to integrins will be carried out in live neuroblastoma cells.
Advanced live cell imaging techniques will be used to dissect the molecular mechanisms implicated. Answers to these questions will help understand cell migration and have potential applications in both tumour biology and neuroscience.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences developmental biology
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.