Objective
Diabetes has a huge global impact, making it one of the priorities of biomedical research. During my post-doc, I characterised a novel gene named DOR - Diabetes and Obesity Regulated, connected with diabetes and obesity. DOR is a nuclear coactivator that enhances the transcriptional activity of several nuclear receptors. Our results suggest a new pathway involved in the pathophysiology of type 2 diabetes. The proposed project aims to understand how the expression of the DOR gene is regulated in skeletal muscle and adipose tissues under normal physiological conditions. For this, after an in silico study of the DOR promoter, the human promoter will be analysed in cultured cell lines of those tissues. We expect to find common regulatory elements, which will be studied with suitable methodologies. Deletion analysis of the promoter will be performed, and regions involved in transcriptional control will be further analysed to identify binding motives and the corresponding transcription factors. Moreover, the role of methylation and of selected pharmacologically active substances in DOR expression will be studied. Further important information about DOR regulation will derive from the analysis of a single nucleotide polymorphism in the promoter. Continuing the characterisation of this novel gene will surely be a major contribution to unravel the aetiology of obesity and type 2 diabetes. The expected results have a great potential to increase the competitiveness of the European biomedical industry and to contribute to better and more cost-efficient health care. This project is the basis for my reintegration into the Institute of my PhD. I return as a group leader to start a new line of research, getting the opportunity to develop an excellent scientific career, aiming at a professorship. This grant will be fundamental for my reintegration, since its financial support will help build a foundation of quality at the international level for my new work group and my career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences clinical medicine endocrinology diabetes
- natural sciences biological sciences genetics nucleotides
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GOETTINGEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.