Objective
The ability of fluorine to alter the physical and chemical properties of organic molecules has been used in the design of drugs and new materials. Fluorinated heterocycles, especially carbohydrates, are very interesting to pharmaceutical and agrochemical industries due to their biological activity. Besides, they can also present other kinds of applications such as preparation of liquid crystals. The present known methodologies in the synthesis of fluorosugars afford mixture of several compounds, diminishing the yield of the reaction and making their purification more difficult. In this project, we propose the intramolecular palladium-catalysed cyclisation of allylic fluorides as a methodology for the preparation of fluorinated heterocycles that can be easily transformed in their corresponding carbohydrates.
The use of allyl fluorides in reactions catalyse for palladium complexes has not been well studied. With this in mind, this project will be based on finding the conditions to conduct the intramolecular palladium-catalysed cyclisation of nitrogen- or oxygen-containing allyl fluorides, affording the corresponding fluorinated 5- or 6-membered-rings. To reach these aims, two methodologies will be used, intramolecular Wacker-type reaction and preparation of allyl palladium complex by elimination of a silylated or an acetate groups, followed by intramolecular cyclisation.
The possibility of preparing the allylpalladium complex by elimination of fluorine or by elimination of the other group (silicon or acetate, depending on the reactivity of the starting material to give the fluorinated complex) will afford different ways of preparing fluorinated or nonfluorinated heterocycles. The allyl fluorides will be synthesised using methodologies developed and learnt during the postdoctoral stage. Finally, it is worthy highlighting the use of chiral ligands to obtain enantiopure compounds.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences chemical sciences inorganic chemistry halogens
- natural sciences chemical sciences organic chemistry alcohols
- natural sciences chemical sciences organic chemistry amines
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-11
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ALICANTE
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.