Objective
The aim of the proposed research is to specify mechanisms of the anisotropic water diffusion in multi-compartmental nervous tissue of the spinal cord, and to correlate them with structure and state of the tissue.
The main investigations will be conducted on an animal model (a rat) in vivo, using a 4.7 T-Magnetic resonance imaging research system dedicated for small animals. Additionally, in vitro measurements using MR Microscope 11.7 T are planned on extracted spinal cord to specify details which will be difficult or impossible to perform in vivo.
Methods of the measurements of anisotropic diffusion, based on spin echo and ultra-short spin echo (UTE) will be used. Results will be correlated with relaxation times T2 and T1 and with histopathology of tissue. It will allow for discrimination between components of the diffusion originating from water of different mobility within myelin, as well as inside and outside axons.
Detailed measurements of the diffusion components in normal spinal cord together with simulations of the diffusion will be used for elaboration of the model of anisotropic diffusion, and for choosing optimal parameters for imaging of the components of the anisotropic and multi-compartmental diffusion in nervous tissue.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences physical sciences optics microscopy
- social sciences sociology social issues social inequalities
- natural sciences mathematics pure mathematics geometry
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-11
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
KRAKOW
Poland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.