Objective
Cancer is a systemic disease characterized by a plethora of epigenetic alterations with extensive disturbances of DNA-methylation that play a crucial and nodal role in carcinogenesis. However, the question that arises is whether similar epigenetic alterations can also take place in genes of immune cells and interfere with the anti-tumour immune response.
The hypothesis underlying this proposal postulates that "spreading" of epigenetic alterations is taking place in cancer affecting the expression of immune genes, and/or other genes of immune cells which, in turn, alter the ability of the immune system to combat tumours. This study approaches the epigenetics of the immune system of cancer patients through their functional consequences on the effector CD8 T cell anti-tumour immune response. Moreover, since one of the tools used for these studies is epigenetic drugs, this project offers a unique methodological approach for screening the efficacy of these on the immune functions, prior to therapeutic applications.
The proposal will drive further our understanding of the tumour-immune system relation, and benefit cancer immunotherapeutics. This innovative approach for cancer immunology creates a fertile common ground upon which the most forefront field of genetics along with cellular immunology will work towards the better understanding of carcinogenetic mechanisms and the improvement of cancer immunotherapy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology lung cancer
- medical and health sciences basic medicine immunology immunotherapy
- natural sciences biological sciences genetics epigenetics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
VOLOS
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.